Operation People First emphasizes that effective care begins and ends with people. People’s Care connects outpatient services (ie. primary care), inpatient services (ie. emergency departments, general wards, and critical care units) and community services (ie. public and population health) into a seamless, people-centered care continuum. This framework ensures that care reaches everyone, everywhere, every time. Lessons from/for the frontlines show that outcomes depend not only on clinical interventions but also on determinants of care such as environment, access, trust, available resources, and social context. In operational and resource-limited settings, these determinants are critical for building resilience, ensuring readiness, and delivering timely, equitable care. Community engagement is essential. Understanding context, local needs, building trust, and leveraging networks ensures that services are effective, responsive, and inclusive. Within this framework, molecular insights can further refine and guide care. Biomarkers (such as Akt and Skp2) are powerful drivers of disease that demonstrate how biology intersects with social and environmental determinants. Beyond their laboratory significance, these molecules act as biological witnesses to inequities that influence who becomes ill, who receives treatment, and who survives. By centering care on people, these markers reveal structural barriers and disparities, enabling systems to address inequities. People’s Care builds on this foundation by emphasizing that disease management extends far beyond prescriptions and procedures. Social, behavioral, and environmental factors often shape outcomes more than clinical interventions alone. Primary care providers, whether in inpatient, outpatient, or transitional settings, are uniquely positioned to address these upstream determinants. Case series presented demonstrate why understanding and addressing determinants of care is essential for improving outcomes, reducing readmissions, promoting quality of life, and advancing equity. Integrating preventive medicine, public health, and primary care allows teams to address root causes of illness systematically, linking care with community resources, interdisciplinary teams, and local public health infrastructure. People’s Sciences provides a framework for integrating people’s context into care practices. By considering social conditions, lived experiences, community dynamics, and environmental factors alongside clinical data, this novel paradigm ensures that care is designed around the realities of those receiving it. This approach underpins the work of the flagship Society of People’s Care, which translates context into practice across the care continuum. The paradigm extends care beyond hospitals and clinics into neighborhoods, workplaces, barracks, and operational theaters, embedding prevention, preparedness, and equity at every level. Operation People First embodies a dual strategy: delivering evidence-based care informed by people’s needs while dismantling barriers that prevent equitable access. By centering people in care, teams achieve resilience and ensure that everyone receives the care they need. Integrating scientific insight with people-centered practice transforms frontline care from reactive interventions into proactive, inclusive systems capable of responding to both routine and crisis needs. Ultimately, Operation People First reframes the mission of care. Treating disease alone is not enough. By placing people at the center, frontline teams can understand context, improve outcomes, reduce disparities, and build a care system that is scientifically advanced and humanistic. This approach ensures care is delivered for everyone, everywhere, every time.