Clinicians often encounter knowledge gaps when transitioning into a new healthcare role or practice setting, even with prior experience. While formal education prepares clinicians for essential role functions, training is often generalized and may not reflect the needs of specific patient populations. The Veteran patient is a population characterized by unique health concerns such as service-related injuries, post-traumatic stress disorder, chronic pain, and complex comorbidities. To promote Veteran-centric care, it is essential to provide clinicians with educational opportunities that demonstrate the distinct experiences and needs of Veterans. Simulation is a well-established strategy for bridging this gap by providing a safe, controlled environment in which clinicians can apply knowledge, refine skills, and build confidence without risk to patients. Virtual reality (VR) simulation extends these benefits, with evidence showing improvements in knowledge retention, competence and confidence while in a satisfactory learning environment. The integration of artificial intelligence (AI) further enhances VR simulation by enabling real-time patient responses based on learner actions and through the creation of highly realistic virtual patients that reflect the unique characteristics of specific populations, such as Veterans. This large, multi-site VA medical center employs over 5,000 staff and teaches more than 500 trainees to serve and care for 84,000 Veterans. To support clinician readiness, the medical center operates a robust simulation center with state-of-the-art manikins and skill trainers, conducting high fidelity interprofessional simulation training and classes daily. Building on this foundation, the center is expanding into virtual reality (VR) education to better prepare clinicians across disciplines. As part of this initiative, VR simulation is being introduced within the medical center’s RN residency program, Physical Medicine and Rehabilitation services, and the Community-Based Emergency Residential Services. The medical center adopted a VR simulation platform that provides a library of standard scenarios with the flexibility to customize content. By integrating AI, highly detailed virtual Veteran patients can be developed to reflect common medical conditions, mental health diagnoses, and complex comorbidities seen in this population. Military history and experiences can also be incorporated, creating more authentic encounters that allow learners to build rapport and engage in realistic clinical scenarios. Through AI-powered VR simulation, clinicians practice critical skills such as clinical decision-making in patients with multifaceted disease processes, therapeutic communication with individuals experiencing mental health crisis, safe de-escalation techniques to protect patients and staff, and comprehensive history-taking for Veterans with challenging health needs. The effectiveness of VR simulation will be assessed using the Simulation Effectiveness Tool-Modified (SET-M) and a hospital-developed questionnaire designed to measure engagement, realism, clinical reasoning, confidence, preparation, knowledge retention, and overall satisfaction. VR simulation may also provide cost saving advantages compared to traditional methods by reducing the reliance on physical resources, equipment, and personnel. By integrating AI-powered VR simulations, clinicians will be better prepared to create a healthy future for our Veterans and nation.