Name
#33 The Paradox of Prevention: How Prophylactic Surgery Accelerated Decline in Metastatic Cancer
Speakers
Content Presented On Behalf Of:
Air Force
Session Type
Poster
Date
Tuesday, March 3, 2026
Start Time
5:00 PM
End Time
7:00 PM
Location
Prince Georges Expo Hall E
Focus Areas/Topics
Clinical Care
Learning Outcomes
Following this session, the attendee will be able to:
1. Interpret guideline-based scoring systems such as Mirels in the context of fracture risk assessment, while recognizing their limitations in accounting for patient frailty, physiological reserve, and overall prognosis.
2. Evaluate the potential impact of major prophylactic surgery on frail patients with advanced malignancy, including the risk of irreversible functional decline and loss of independence.
3. Apply shared decision-making principles to balance fracture prevention with realistic discussions about functional outcomes, dependency, and quality of life.
4. Recognize the importance of early palliative care involvement to align surgical decisions with patient values, goals, and overall care preferences.
1. Interpret guideline-based scoring systems such as Mirels in the context of fracture risk assessment, while recognizing their limitations in accounting for patient frailty, physiological reserve, and overall prognosis.
2. Evaluate the potential impact of major prophylactic surgery on frail patients with advanced malignancy, including the risk of irreversible functional decline and loss of independence.
3. Apply shared decision-making principles to balance fracture prevention with realistic discussions about functional outcomes, dependency, and quality of life.
4. Recognize the importance of early palliative care involvement to align surgical decisions with patient values, goals, and overall care preferences.
Session Currently Live
Description
Background: Metastatic castration-resistant prostate cancer (mCRPC) commonly involves bone metastases, with a high risk of pathological fractures that can lead to significant morbidity. Prophylactic fixation is often recommended based on scoring systems like Mirels. However, the decision to proceed with major surgery in elderly, frail patients with advanced disease poses complex challenges, as the physiological stress of surgery may outweigh its potential benefits.
Case Presentation: We present the case of an 86-year-old male with end-stage mCRPC and high-risk bilateral proximal femoral lesions who underwent guideline-concordant prophylactic bilateral cephalomedullary nailing. While the surgery successfully prevented fractures, his postoperative course was marked by severe anemia, transfusion reactions, hematuria, and a rapid functional decline. Within weeks, he became non-ambulatory and dependent on activities of daily living. Despite multidisciplinary management, he transitioned to home hospice within six weeks of surgery to prioritize comfort and quality of life. This case underscores the critical disconnect that can occur between technical surgical success and patient-centered outcomes in advanced cancer. While clinical guidelines and scoring tools like Mirels provide valuable direction, they do not account for patient frailty, life expectancy, or functional reserve. In this instance, the intervention may have inadvertently hastened the patient's decline, emphasizing the importance of early palliative care involvement and shared decision-making that incorporates discussions around prognosis, functional outcomes, and individual goals of care.
Conclusion: In patients with advanced malignancy and limited reserve, the physiological burden of prophylactic surgery may undermine their remaining quality of life. A nuanced, multidisciplinary approach is essential to align treatment plans with patient values and priorities.