Background: During World War II, U.S. medical logistics evolved into a decisive enabler of operational success across the Pacific. The Navy and Army medical departments built distributed, resilient networks that sustained forces across 7,000 miles of ocean. Forward-deployed fleet hospitals, amphibious surgical ships, modular medical equipment, and industrial supply systems turned logistical innovation into combat survivability. Objective: This project synthesizes lessons from military historical accounts (e.g. FMFRP 12-12, ADA291602) and modern doctrine to understand joint medical sustainment adaptations in the Pacific Theatre and enduring logistics principles for modern Indo-Pacific operations. Findings: WWII fleet hospitals and LST(H) ships mirrored today’s need for afloat Role 2/3 nodes under distributed maritime operations. Joint coordination under the South Pacific Base Command anticipated CJADC2-style interoperability. Public–private collaboration (penicillin, blood plasma, sterile packaging) reflected the mobilization of logistics on a national scale. WWII medical supply officers emphasized demand forecasting and modular outfitting, paralleling today’s AI-based predictive sustainment efforts. Policy Recommendations: Develop floating Role 2/3 nodes and expand joint prepositioned medical stocks across the First and Second Island Chains. Establish allied medical interchange agreements for rapid substitution in coalition operations. Incorporate AI-based MEDLOG visibility into CJADC2 and joint theater planning. Conduct medical Joint Logistics Over-the-Shore (JLOTS) exercises that replicate contested sustainment under fire. Conclusion: WWII’s joint medical logistics innovations provide a historical blueprint for modern Indo-Pacific sustainment. Policy success requires anticipatory planning, cross-service standardization, and integration of industry and allies.