Genomic medicine is a critical component of evidence-based, guideline-directed clinical care. Despite growing clinical recommendations, genetics in medical practice remains critically underutilized. Effective translation of genomic medicine to improve patient care is significantly hindered by persistent gaps in healthcare provider knowledge and clinical confidence regarding genetics. The Military Health System (MHS) is not an exception, with similar underutilization as well as providers reporting low knowledge and confidence regarding clinical genetics. Addressing these gaps requires a strategic optimization of clinical genetics education, starting in medical training. The Uniformed Services University (USU) School of Medicine (SoM) trains approximately 25% of active-duty military doctors and, therefore, improvements in genetics education at USU could have a broad impact on patient care throughout the MHS. The GENEIUS study aims to enhance a military pre-clerkship clinical genetics curriculum at the USU to better prepare future MHS physicians for the era of genomic medicine. The GENEIUS study follows Kern’s 6 steps for curriculum improvement, applying a longitudinal and cross-sectional approach that collects both quantitative and qualitative data to: 1) Evaluate student performance in the pre-clerkship genetics curriculum; 2) Explore student self-perceptions of the effectiveness of pre-clerkship genetics curriculum for preparation for assessments and clinical practice; and 3) Implement and assess the impact of annually updated, data-informed curricular revisions. This study has been approved by the USU IRB (DBS.2025.943). Following USU SoM graduating classes of 2027 through 2033, student performance is appraised via exams scores from the assessments given during the clinical genetics curriculum, the National Board of Medical Examiners (NBME) assessment, and the United States Medical Licensing Examination (USMLE) Step 1 assessment. Students’ perceptions of the effectiveness of the genetics curriculum are collected through a voluntary focus group held after their initial experience with the curriculum and following completion of the USMLE Step 1 assessment. Finally, on an annual basis, these data will be compared and analyzed to make targeted improvements to clinical genetics educational content and strategies for medical students. This research is innovative in its utilization of longitudinal and cross-sectional study design, as well as collecting both quantitative and qualitative data to implement an iterative and responsive curriculum optimization model addressing critical gaps in genetics education. Moreover, the research team is making use of advanced technologies for data analysis, including AI-supported content analysis to drive iterative, evidence-based curriculum improvements. With the goal of equipping future physicians with essential genetics and genomics knowledge and confidence, the GENEIUS study addresses the need for competent and confident providers who are prepared to apply genetic information in clinical decision-making, ultimately leading to improved patient care and health outcomes. Disclaimer: The opinions and assertions expressed herein are those of the author(s) and do not reflect the official policy or position of the Uniformed Services University of the Health Sciences or the Department of Defense.