The Department of Veterans Affairs (VA), the nation’s largest integrated healthcare system, embeds research within clinical care, enabling discoveries to more rapidly translate into practice, better meet the needs of Veterans, and support both Administration / Departmental and Congressional priorities. The Office of Research and Development (ORD) plays a central role in advancing an enterprise-wide strategy that organizes research into coordinated project groups known as portfolios. Among these, Actively Managed Portfolios (AMPs) are specifically designed to accelerate discovery and translation in response to statutory, administrative, and Veteran-identified priorities in high-impact areas of Veteran health. ORD’s model takes advantage of VA’s unique environment as a federal healthcare system with research embedded to facilitate greater partnership and integration between evidence generation and clinical care. This structure ultimately improves Veteran care and generates insights that benefit the nation. AMPs align resources, data, and expertise with implementation efforts across VA’s learning health system, operating as interdisciplinary networks of researchers, clinicians, and operational leaders focused on addressing specific health challenges. AMPs leverage end-user input, clinical data, scientific innovation, and VA enterprise resources, such as the Million Veteran Program (MVP), Cooperative Studies Program, and Quality Enhancement Research Initiative (QUERI), to support a more rapid, repeatable path from discovery to testing to scale-up in routine care settings. This approach can serve as a model for sustaining embedded research in other health systems. Precision health is delivering the right care at the right time for the Veteran and is rapidly advancing through innovations in data science. However, translation from research to practice is often limited by systematic barriers. AMPs aim to bridge this divide by fostering transparency, accountability and measurable impact through shared data resources and stakeholder learning communities, consistent with VA’s translation to Policy Learning Cycle. At the core of VA’s precision health efforts is the Million Veteran Program (MVP), one of the world’s largest and most diverse genomic and health research cohorts, with over one million enrolled Veterans and more than 450 scientific publications. MVP provides secure, research-ready datasets that integrate genetic and epigenetic, clinical, lifestyle, military exposure, and environmental data, offering an unmatched resource for discovery and implementation. By enabling integrated analyses across multiple data types, MVP supports AMPs in advancing biomarker discovery and precision medicine applications. Several AMPs demonstrate ORD’s precision health impact and its emphasis on collaborative, team-based approaches to transformative care for Veterans. These include Precision Oncology, Suicide Prevention, Traumatic Brain Injury, Military Exposures, and Pain and Opioid Use. A key resource leveraged by these AMPs is MVP, alongside VA’s electronic health records and other condition-specific datasets tailored to the needs of Veterans. This presentation will summarize VA’s organizational and coordinated research approach to precision medicine across four domains—genomics, brain and mental health, oncology, and suicide prevention, with the goal of providing Veterans access to the highest-quality care through innovative, collaborative, and translational research. Together, the VA’s portfolio structure, MVP resources, and AMP framework demonstrate how an integrated federal research system can transform discovery into improved care for those who have served.