The first commercial negative pressure wound therapy (NPWT) system, Solventum™ V.A.C.® Therapy, was introduced in 1995 and has become the global leader in NPWT. NPWT promotes an environment for wound healing by protecting the wound from external contamination, providing a moist wound environment, and promoting the formation of granulation tissue. This integrated NPWT system is comprised of specialized dressings, adhesive drape, pressure sensing pad, and multi-lumen tubing that connects the wound to the therapy unit, enabling real-time pressure monitoring and fluid management via a disposable canister. Clinical outcomes of V.A.C.® Therapy have been documented in more than 1,700 peer-reviewed publications and 79 randomized clinical trials. Technical advances have expanded NPWT modalities; when used alongside good clinical and field care practices, these systems enable healthcare providers to deliver life- and limb-saving care across the wound healing continuum and diverse operational environments. While these options have expanded the potential to manage a wide variety of wounds in patients, they can complicate product selection. This presentation will highlight distinguishing features of available NPWT systems, including traditional NPWT, NPWT with instillation and dwell (NPWTi-d) of topical wound cleansing solutions, closed incision negative pressure therapy (ciNPT), and open abdomen negative pressure therapy (OA-NPT). Clinical evidence will be presented demonstrating how these wound management solutions can impact the military wound care pathway—from the battlefield, through evacuation to acute and ambulatory care in hospitals and clinics, and into the home. This session will describe key technological innovations, clinical evidence, and best practices supporting the use of NPWT based on treatment goals and military echelons of care. Participants will gain actionable knowledge to optimize wound healing, improve patient outcomes, and support readiness and recovery in the context of wounds managed within both the Department of War and the Department of Veterans Affairs.