Name
#1 - Feasibility of Endovascular Localization of Non-Compressible Torso Hemorrhage Using Swine (Sus scrofa): A Pilot Study
Date & Time
Monday, February 12, 2024, 12:00 PM - 7:00 PM
Description

Non-compressible torso hemorrhage (NCTH) is a common cause of mortality in civilian and military trauma. The development of resuscitative endovascular balloon occlusion of the aorta (REBOA) for vascular injuries in the torso and pelvis transformed the treatment of lethal hemorrhage but is a non-targeted means of hemorrhage control. REBOA is primarily used as a bridge to open control of hemorrhage and reconstruction. The goal of this pilot study was to develop an animal model in swine (Sus scrofa) to determine the feasibility of endovascular localization of NCTH with intravascular ultrasound (IVUS) and a novel prototype multi-sensor pressure catheter (MSPC). Twelve female swine were divided into four groups: abdominal or thoracic aortic injury assessed with either IVUS or MSPC. The thoracic or abdominal aorta was exposed. Baseline pre-injury data was gathered from each endovascular device prior to creation of a uniformly sized aortic injury. In the IVUS group, the IVUS was advanced to identify the site of free hemorrhage which was confirmed by open exposure with visual feedback on IVUS and diagnostic imaging of free hemorrhage. In the MSPC group, an aortic occlusion balloon provided hemostasis during abdominal closure after which the balloon was deflated to allow free hemorrhage. The MSPC was left in place to record pressure data from sensors above and below the site of injury. Twelve female animals entered the study averaging 82 kilograms. At injury, mean arterial pressure was 58mmHg with an arteriotomy size averaging 3mm. IVUS imaging demonstrated several diagnostic clues to free hemorrhage to include aortic wall disruption, a swirling pattern with ChromaFlo, and the ability to confirm aortic control using ChromaFlo. MSPC, which is novel for hemorrhage assessment and localization, demonstrated the ability to capture simultaneous data above and below the injury for future diagnostic applications. REBOA revolutionized point-of-care hemorrhage control for NCTH but lacks the ability to localize site of injury to target balloon placement and primarily serves as a bridge to intervention. This pilot study demonstrates a model for analyzing future endovascular adjuncts to REBOA such as IVUS and the novel MSPC. This study demonstrates a reproducible animal model for testing future endovascular diagnostic and treatment modalities as well as unique IVUS findings with lethal aortic hemorrhage.

Location Name
Prince Georges Exhibit Hall A/B
Content Presented on Behalf of
DHA
Learning Outcomes
1.Discuss past and current operative and non-operative methods utilized on the battlefield and at overseas medical treatment facilities to control and/or temporize and definitively treat non-compressible torso hemorrhage.
2.Discuss the pitfalls in the current methods of aortic hemorrhage temporization and the adverse consequences they can have on patients.
3.Describe the animal model developed to identify hemorrhage from an aortic injury.
4.Describe the differences between the data that can be collected using intravascular ultrasound (IVUS) and the multisensor pressure catheter (MSPC) and how these technologies can augment REBOA in future applications.
5.Analyze IVUS images to determine the visual differences between an uninjured aorta and an aorta with a greater than 3mm injury with active bleeding.
Session Type
Posters
Dropdown Content Presented On Behalf Of:
DHA