The Department of Veterans Affairs (VA) and Department of Defense (DoD) Clinical Practice Guidelines (CPG) are developed and updated based best information available at the time of publication and are designed to provide information to educate and aid healthcare teams in clinical decision making. Since the release of the 2017 VA/DoD Posttraumatic Stress Disorder and Acute Stress Disorder clinical practice guideline the growing body of literature has expanded the base of evidence as well as the overall understanding of posttraumatic stress disorder (PTSD), as such, the update of the 2017 PTSD guideline was initiated in 2022. Posttraumatic Stress Disorder (PTSD) has an overall estimated prevalence of 6.1% in the general population and between 4 -17% in Service Members. This Clinical Practice Guideline (CPG) intends to promote evidence-based management of PTSD and thereby improving patient’s clinical outcomes. The CPG is designed to assist primary care and mental health clinicians and specialists in the diagnosis of PTSD, using a patient-centric approach in determination of appropriate treatment, and delivery of individualized interventions with a focus on mental health recovery. The Department of Veterans Affairs / Department of Defense (VA/DoD) Evidence-Based Practice Work Group convened a joint VA/DoD guideline development effort that included an interdisciplinary panel of practicing clinician experts. The clinician experts developed key questions in collaboration with the ECRI Institute, which systematically searched and evaluated published clinical literature through May 4, 2022. Recommendations are based on a systematic review of the scientific evidence, a weighing of the benefits and harms of interventions, consideration of what is known about patient values and preferences, and consideration of the applicability of the evidence across demographic groups and settings, by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. This CPG is intended to promote evidence-based management of PTSD and thereby improve patient’s clinical outcomes. Reducing mental health morbidity is important for the health and well-being of active-duty service members, veterans, and their families. This poster presentation summarizes key features of the CPGs: the appropriate diagnosis of PTSD, target treatment goals, algorithms, and nonpharmacologic and pharmacologic treatments.