In the twenty years since the Department of Homeland Security (DHS) was created in light of 9/11, our world has changed. It has grown more interconnected and is facing an unprecedented range of threats, risk and vulnerabilities. Despite the evolution of these challenges over the last 20 years, DHS has remained steadfast in its commitment to safeguard the American people, our homeland, and our values. The legacy distinction between homeland security and health security challenges has become one and the same and the role of DHS has grown accordingly. DHS components and offices continue to address the most pressing challenges to healthcare and public health delivery, within its workforce, those in the Department’s care and custody, and for the nation. The more than 22 operating units that comprise DHS are on the frontlines of rapidly emerging technologies, evolving cyber capabilities, and increasing economic and political instability around the world are contributing to a heightened threat environment at home. DHS has the third largest workforce in the Federal Government with a unique position in the shared federal mission of serving those who serve our nation. This panel will feature five (5) DHS senior leaders who will share their perspectives on the collaborative work done across the agency to serve its workforce comprised of over 260,000 employees including over 50,000 veterans, and the nation. The speakers will share why a “One DHS Health” is needed now more than ever to ensure alignment across responses that are increasing in number and complexity. In the last two decades that separate these touchstones of the Department of Homeland Security, we see our origins and our future. The Department was born of tragedy and necessity; in that necessity, however, DHS has evolved and matured to meet the Homeland’s greatest challenges over the past 20 years.