Diabetes, obesity, hypertension, and cardiovascular and respiratory diseases, are risk factors for the poor health outcomes resulting from heat waves, wildfires, and other natural disasters. A high prevalence of chronic conditions in racial and ethnic minority populations and other underresourced and medically underserved populations experiencing social discrimination in the United States is largely attributable to differences in multigenerational discrimination, living conditions, and societally mediated stressors, which are often collectively called the social determinants of health (SDOH). Community resilience to the health impacts of climate change can be built by community-led solutions. Climate interventions and resources that address the social determinants of health can reduce risk to adverse outcomes related to climate. Holistic coordination of disparate funding and resource streams into place-based solutions can mitigate the climate risks associated with legacy place-based inequities. One such place-based, community led model for addressing climate health risks is that of resilience hubs. Resilience hubs are trusted physical sites that can serve as gathering spaces and response centers during periods of disruption and recovery, and benefit the community year-round. The resilience hub model favors a combination of strategies that retrofit or otherwise improve a building envelope and surrounding landscape, develop energy efficiency and energy independence, and reduce greenhouse gas emissions while simultaneously providing programs and services tailored to the needs of the community, such as meal services, mental health, employment assistance, housing assistance, and children’s programming. These programs and services implicitly provide community benefits targeting SDOH and, therefore, build resilience to climate change and extreme weather events. The resilience hub can improve linkages of community services-to-healthcare and healthcare-to-community services by co-locating health services or a community health center or a hospital satellite office. Resilience hubs can improve healthcare engagement and delivery for people with climate-sensitive conditions and thereby improve their outcomes. Community initiatives that promote convening of funders and partners dedicated to local priorities can be leveraged to create and sustain resilience hubs. The Promise Zone Initiative, supported by the Department of Housing and Urban Development and the Department of Agriculture, may be particularly well suited to support resilience hubs by facilitating technical assistance, funding support, and convening of local, state, and federal resource partners.