Long COVID, defined as the signs, symptoms, and conditions that continue or develop after initial SARS-CoV-2 infection, is a newly emerged infection associated chronic illness. Recent studies have estimated that 6% of US adults are expecting Long COVID with 25% of these people experiencing activity limitations. The underlying pathophysiologic cause of Long COVID is not known, but research efforts have identified that immune dysregulation, microbiota dysbiosis, autoimmunity, endothelial abnormalities or dysfunctional neurological signaling may play a role in the illness. There is a need to understand how to provide clinical care to patients with Long COVID, to understand what treatments are effective, and to understand how to best support patients with Long COVID in their communities. A multifaceted condition like Long COVID can impact all aspects of life, from health and wellbeing, to ones ability to work, take care of themselves and their family and support themselves financially. A multidisciplinary response within the United States Government is therefore necessary. In 2022, the White House issued a memorandum organizing the government-wide response to addressing Long COVID and the longer-term impact of COVID-19. The response to Long COVID requires the advancement of research, clinical practices, supports and services, public education, and coordination. To allow for interagency coordination, the Department of Health and Human Services created the Long COVID Coordination Council (LCCC) and is chaired by ADM Rachel Levine, the Assistant Secretary for Health. There are 14 different agencies that participate in the LCCC, including 17 different divisions from the Department of Health and Human Services. The long-term voluntary participation of agencies across the United States Government in the LCCC is positioned to create unprecedented change in the response to infection associated chronic conditions. These efforts will have impacts on policy and will have implications for innovators outside the government, allowing the wisdom and experience of a variety of stakeholders to be included in the response to Long COVID. To allow specific coordination, the LCCC created seven work groups, focusing on communications and partnerships, service eligibility, coverage access and payment, data and surveillance, research, clinical practice, and behavioral health . Recently, the Office of Long COVID Research and Practice was established within the Office of the Assistant Secretary for Health to lead the Long COVID response and coordination across the federal government. The Office of Long COVID uses the infrastructure of the LCCC to coordinate the release of communications products, encourage collaboration of research studies, and disseminate updates between agencies. The Office of Long COVID ensures the broad engagement of stakeholders to address the multifaceted nature of Long COVID. Future efforts will focus on answering the research questions raised in the National Research Action Plan on Long COVID, coordinating the development of clinical practice guidelines, and identifying the best ways to provide care for patients with Long COVID.