The aim of this study was to analyze preclinical in-vitro and in-vivo characteristics of different hydrophobic and innovative ultra-hydrophilic titanium (ti) implant surfaces with different surface modifications for maxillofacial reconstructions. Surface characteristics and osseointegration of acid-etched (ae), ultra-hydrophilic (uh), micro- and nano-structured (ms, ns) implant surfaces were compared to non-ultra-hydrophilic (nuh) micro-structured implant surfaces. For in-vitro characterization, the amount of salt on salt-coated nanostructured implants was determined by conductivity measurement of the washing solution. Micro- and nanostructured implants were investigated concerning surface characterization with salt layer by conductivity measurement, scanning electron microscopy (SEM) and energy disperse X-ray analysis (EDX). Contact angles of the different surfaces were measured by the method of Wilhelmy using a tensiometer and by the sessile drop method using pico-liter volumes. 3D optical profilometry was used to analyze roughness parameters. For in-vivo characterization, 54 implants (SA (ae, ms, nuh, sb (sandblasted)); AN (ae, ms, ns, nuh, nsb ((non-sandblasted)); ANU (ae, ms, ns, uh, nsb); n=18 each), were bilaterally inserted into the proximal tibia of New Zealand rabbits (n=27) to analyse osseointegration. After 1, 2 and 4 weeks, bone-implant contact (BIC, %) in the cortical (cBIC) and spongious bone (sBIC), bone chamber ingrowth (BChI, %), and the supra-crestal, subperiosteal amount of newly formed bone, called percentage of linear bone fill (PLF, %), were analysed. In-vitro results showed that salt-coating of micro- and nano-structured implants lead to a homogenous, dark grey look. The amount of salt per species was 165 ± 23 µg. Appropriately the amount of salt per surface area was 56 ± 8 µg/cm². Concerning SEM, samples reveal a distinct and homogenous micro-structure with valley and sharp peaks independently from the position. Also, a distinct and homogenous nanostructure containing very dense packed needles and spheroids with a size of 10-30 nm was found. According to Wilhelmy contact angle measurement, salt-coated, micro- and nanostructured implants displayed hyper-hydrophilic wetting properties with high imaginary contact angles after base line correction and negligible hysteresis. Implants displayed at all positions this type of wetting behavior defined as contact angle of 0° confirming the results of the contact angle measurement by Wilhelmy within the limits of these two methods. The mean Ra values ranged between 0.66 and 0.92 µm. The Sa values were slightly higher laying in the range between 0.76 and 1.02 µm. The mean Sdr values lay in the range between 79 % and 96 %. In-vivo results showed that after one-week, cBIC was significantly higher for AN and ANU when compared to SA (p=0.01 & p=0.005). PLF was significantly increased for ANU when compared to AN and SA (p=0.022 & p=0.025). After 2 weeks, cBIC was significantly higher in SA when compared to AN (p=0.039). After 4 weeks, no significant differences in any of the measured parameters were found anymore. Significant differences concerning the differently modified ti implant surfaces were shown. An accelerated and improved osseointegration by ultra-hydrophilic ti implant surfaces could be useful for reconstructions in severe combat-related maxillofacial injuries.