Disclaimer: The views expressed in this abstract are those of the author and do not necessarily reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or U.S. Government Introduction The VA and DoD Evidence-Based Practice Work Group (EBPWG) was established and first chartered in 2004, with a mission to advise the VA/DoD Health Executive Committee “on the use of clinical and epidemiological evidence to improve the health of the population . . .” across the Veterans Health Administration (VHA) and Defense Health Agency (DHA), by facilitating the development of clinical practice guidelines (CPG) for the VA and DoD populations.(1) In July 2020, the VA and DoD published a CPG for The Primary Care Management of Headache, which was based on evidence reviewed through March 2019. Since the release of that CPG, the evidence base on Headache has expanded. Consequently, the EBPWG initiated the update of the 2020 VA/DoD Headache CPG in 2023. This updated CPG’s use of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach reflects a more rigorous application of the methodology than previous iterations.(2) Therefore, the strength of some recommendations may have been modified due to the confidence in the quality of the supporting evidence. Materials and Methods As the abstract is devoid of patient identifiable information, it is exempt from IRB review requirement as per VA DoD policy. Results/Case Report The updated CPG reflects a growing number of abortive and preventive pharmacotherapies and neuromodulation available for the management of migraine and other types of headaches. This CPG includes recommendations on the following key topics: •Evaluation and management of Medication Overuse Headache (MOH) •Pharmacotherapies •Injections, infusions, and procedures •Neuromodulation •Behavioral interventions •Rehabilitation approaches, including exercise •Complementary and integrative health (CIH), including nutraceuticals •Comparative effectiveness of acute and preventive pharmacotherapies •Role of combination therapies Discussion This CPG provides an evidence-based framework for evaluating and managing care for individuals living with Headache toward improving clinical outcomes. Successful implementation of this CPG will: •Assess the patient’s condition and collaborate with the patient, family, and caregivers to determine optimal management of patient care; •Emphasize the use of patient-centered care and shared decision making; •Minimize preventable complications and morbidity; and •Optimize individual health outcomes and quality of life (QoL). This CPG and algorithm are designed for adaptation by individual health care providers with respect to unique patient considerations and preferences, local needs, and resources. The algorithm serves as a tool to prompt providers to consider key decision points in the care for a patient with Headache, encouraging to use a patient-centered, whole/holistic health approach. References 1.U.S. Department of Veterans Affairs/Department of Defense Health Executive Committee (HEC). Evidence Based Practice Work Group Charter [updated January 9, 2017]. Available from: www.healthquality.va.gov/documents/EvidenceBasedPracticeWGCharter123020161.pdf. 2.Guyatt GH, Oxman AD, Kunz R, Atkins D, Brozek J, Vist G, et al. GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol. 2011;64(4):395-400. Epub 2011/01/05. doi: 10.1016/j.jclinepi.2010.09.012. PubMed PMID: 21194891.