This presentation will spotlight the Nurse Run Protocol (NRP) for Self-Collected Vaginal Samples developed by the Female Force Readiness Navy Medicine Operational Clinical Community (FFR NMOCC), a multidisciplinary body of 230+ Navy and Marine Corps leaders and providers championed by the Navy Medicine Office of Women’s Health (OWH) to optimize medical readiness, resiliency, and lethality of the female force. Under the leadership of CDR Teri Ryals (CNM, Navy Medicine Readiness and Training Command (NMRTC) Bremerton) and LCDR Sharon Stortz (Staff Physician, NMRTC Okinawa), the NRP was developed to increase patient comfort, advance trauma-informed care, and reduce the burden on emergency department (ED) physicians related to vaginal health. According to the Women’s Reproductive Health Survey (WRHS) released in 2022, 30% of active duty service women (ADSW) reported a vaginal infection and 10% reported a yeast infection during deployment. Symptoms related to vaginal infections may cause ADSW to lose duty time and experience increased physical, social, and psychological discomfort. Given the common nature of vaginal health related issues, this protocol was conceptualized to determine if patient access to self-swabs for vaginal discharge samples would remove barriers to accessing vaginal healthcare and reduce burden on ED clinicians by decreasing unnecessary ED visits. To address this issue, the FFR NMOCC developed a set of resources to support nurse management of patient-collected vaginal discharge swabs, including a written job aid to guide nurses in administering the protocol, a patient education guide (‘What to Know: Vaginal Discharge’) outlining normal vs. abnormal discharge, and an instructional step-by-step guide for patients self-collecting vaginal discharge samples. To evaluate the impact of the resources, the FFR NMOCC deployed a pilot to utilize these resources across three sites and collect feedback on their usefulness. The three pilot sites included United States Ship (USS) Bush, NMRTC San Diego, and NMRTC Twentynine Palms. Each pilot site was able to make minor modifications to the protocol to align with the available facility resources. The FFR NMOCC obtained feedback from patients and nurses to strengthen the protocol and ensure effective continued use. Pilot results indicated the protocol strengthened the agency service women have over their medical visits, increasing their ability to remedy common women’s health concerns. Results from user feedback revealed that 81% of patient survey respondents from the USS Bush agreed or strongly agreed they would self-collect a sample of vaginal discharge again if they had a similar health concern in the future. Based on pilot feedback, the FFR NMOCC developed an implementation guide to provide instructions to leaders interested in replicating this protocol across the Navy enterprise. This process improvement effort provides a proof of concept for an innovative, self-driven healthcare option for female service members to increase deployability and readiness.