Nurses have played a crucial role in the battle against COVID-19. Their roles and responsibilities have evolved significantly, primarily focusing on being liaisons and subject matter experts to ensuring the effective utilization of COVID-19 therapeutics.​Nurses engaged with ASPR stakeholders (state/territorial/local health departments, professional organizations, applicable advocacy groups, private sector partners such as pharmacies). ​ To provide an outline of the key responsibilities and objectives of clinicians during the COVID -19 pandemic response.​ To provide a clear understanding the roles clinicians play in collaborating with interdisciplinary teams:​ disseminating accurate information​ promoting public health measures​ adapting to evolving guidelines​. Nurses collaborated with stakeholders and established monoclonal antibody infusion centers. They supported clinical grand rounds and created a collaborative document with FAQs for stakeholders and other federal partners. They created Clinical Implementation Guidelines (CIG), Side by Side (SXS) and Decision Aids (DA). Their multifaceted roles as liaisons and subject matter experts have not only facilitated the understanding of clinical aspects of COVID-19 therapeutics among healthcare staff but have also fostered collaboration with diverse stakeholders, contributing to a more comprehensive and effective response to COVID-19.​ One of their primary roles has been that of a liaison, bridging the gap between clinical knowledge and the broader community of stakeholders. They are responsible for disseminating the latest clinical guidelines, sharing best practices, and addressing any emerging challenges in real-time​.