Hemorrhagic shock due to rapid blood loss leads to organ damage and death. Differences in blood pressure oscillations between high compensators and low compensators to hemorrhage may be useful to predict which combat casualties are at greatest risk of death. Wearable deep tissue oximetry sensors may be able to detect hemorrhage everity and predict patient risk level remotely, allowing for rapid andtargeted treatment. NIRSense is developing a platform called Aegis using near-infrared spectroscopy (NIRS) to be used in prolonged fieldcare, where patients may be supported for up to 72 hours. Thirty-one anesthetized female swine (35-75 kg) were used as subjects. Tissue oximetry was monitored using 3 Aegis sensors and 2 Medtronic INVOS 5100C sensors, positioned to avoid interference. The swine underwent lung contusion, bilateral femur trauma, and 40-50% controlled hemorrhage (≤60 mL/min) without resuscitation. Monitoring continued for 4 hours or until exclusion criteria were met. The NIRSense Aegis deep tissue oximeter performed equivalently to the gold-standard INVOS 5100C in monitoring tissue oxygenation in a swine polytrauma and hemorrhage model. Additionally, StO2 relative changes effectively reflected mean arterial pressure variations during hemorrhage, especially at the head location. Further work is being done to determine how deep tissue oximeter may be utilized to rapidly and continuously provide profession monitor of trauma patients.