Death by suicide is a profound and complex issue that significantly impacts both the general and military populations. It represents a critical public health crisis reflecting deep-seated mental health challenges and the urgent need for effective interventions. The annual rate of death by suicide among adults in the United States (U.S.) increased over the first two decades of the 21st century. In 2021, there were 18.0 deaths per 100,000 population, compared to the age- and sex-standardized rate of 14.2 per 100,000 in 2001. Unstandardized suicide mortality rates in 2021 were similar across age groups, ranging from 16.2 per 100,000 for those 25–29 years of age to 19.8 per 100,000 for those 60–64 years of age. Historically, the U.S. military population had a lower rate of suicide than the general population. The increase observed since the early 2000s has brought the active-component military suicide mortality rate closer to the general population rate after accounting for age and sex differences between the two populations. In 2021, the suicide mortality rates per 100,000 for the active component, National Guard, and Reserves were 24.4, 27.1, and 21.8, respectively. The Veterans Affairs (VA) and the Department of Defense (DoD) prioritize the reduction of suicide risk through evidence-based interventions. The VA/DoD Evidence-Based Practice Work Group convened a joint VA/DoD guideline development effort that encompassed a multidisciplinary panel of practicing clinician experts and conformed to the Institute of Medicine's tenets for trustworthy clinical practice guidelines (CPGs). The guideline panel developed key questions in collaboration with the ECRI Institute, which systematically searched and evaluated a total of 103 publications. Recommendations are based on a systematic review using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. This guideline is intended to promote evidence-based assessment and management of patients at risk for suicide and improve patient’s clinical outcomes. The CPG is designed to assist primary care and mental health clinicians and specialists in screening for suicide risk, determination of appropriate treatment, and delivery of individualized interventions. Reducing mental health morbidity is important for the health and well-being of active-duty Service Members, Veterans, and their families. This poster presentation summarizes key features of the CPGs: screening, assessment, risk management and treatment.