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BEGIN:VEVENT
UID:c49120c0b1f810337f0fb64524abec58942b296b@swoogo.com
DTSTAMP:20260616T221128Z
DESCRIPTION:Loiasis is a parasitic disease caused by the African eye worm L
 oa loa. The disease is endemic to the equatorial rain forest and adjacent 
 areas of Central and West Africa\, where it is transmitted by deer flies o
 f the genus Chrysops. Although more than 23 million people are infected an
 d nearly 42 million live in zones of moderate to high transmission\, there
  are currently no established control tools available to reduce the risk o
 f transmission in endemic regions. Despite the fact that the use of repell
 ents has been explored against other arthropods\, data on their protective
  efficacy against Chrysops bites in humans is lacking. Our group have esta
 blished randomized controlled clinical trial protocols to assess the effic
 acy of four commercial skin-applied and two textile-applied repellents aga
 inst Chrysops bites in a hyperendemic region in Gabon\, Central Africa. In
  the first trial\, volunteers were randomly assigned to apply the skin rep
 ellents DEET\, icaridin\, citriodiol\, IR3535 or an inactive control. The 
 primary endpoint was the number of blood meal attempts by Chrysops flies. 
 Secondary outcomes were the frequency and duration of Chrysops landings on
  clothing and skin. The results of the first trial are as follows: regardi
 ng the tested skin-repellents\, blood meal attempts were significantly red
 uced by citriodiol (-50%\, p=0.04) and DEET (-50%\, p<0.001)\, but not ica
 ridin (0%\, p=0.48) and IR3535 (0%\, p=0.69). Concordantly\, the time spen
 t by the fly on the skin was significantly shortened by citriodiol (-66%\,
  p=0.02) and DEET (-46%\, p<0.001)\, but not with icaridin (+2%\, p=0.35) 
 and IR3535 (0%\, p=0.93). Conversely\, the number of Chrysops landings on 
 untreated clothing was not reduced by DEET and icaridin\, while citriodiol
  and IR3535 treated individuals experienced a higher number of landings (p
 =0.005 and p=0.01\, respectively). Because our study showed a substantial 
 but not complete protective efficacy of citriodiol and DEET against the bi
 tes of loiasis vectors\, whereas icaridin and IR3535 proofed to be ineffec
 tive\, a second trial has recently started to compare the efficacy of the 
 commercial textile-repellents permethrin and icaridin alone or in combinat
 ion with skin-applied citriodiol and DEET. The available results thereof w
 ill be also presented here.
DTSTART:20260303T220000Z
DTEND:20260304T000000Z
LAST-MODIFIED:20260616T221128Z
LOCATION:
SEQUENCE:0
STATUS:CONFIRMED
SUMMARY:#67 Exposition prophylaxis against the African eye worm: methods to
  prevent loiasis transmission when travelling to endemic regions
TRANSP:OPAQUE
X-ALT-DESC;FMTTYPE=text/html:Loiasis is a parasitic disease caused by the A
 frican eye worm Loa loa. The disease is endemic to the equatorial rain for
 est and adjacent areas of Central and West Africa\, where it is transmitte
 d by deer flies of the genus Chrysops. Although more than 23 million peopl
 e are infected and nearly 42 million live in zones of moderate to high tra
 nsmission\, there are currently no established control tools available to 
 reduce the risk of transmission in endemic regions. Despite the fact that 
 the use of repellents has been explored against other arthropods\, data on
  their protective efficacy against Chrysops bites in humans is lacking. Ou
 r group have established randomized controlled clinical trial protocols to
  assess the efficacy of four commercial skin-applied and two textile-appli
 ed repellents against Chrysops bites in a hyperendemic region in Gabon\, C
 entral Africa.\nIn the first trial\, volunteers were randomly assigned to 
 apply the skin repellents DEET\, icaridin\, citriodiol\, IR3535 or an inac
 tive control. The primary endpoint was the number of blood meal attempts b
 y Chrysops flies. Secondary outcomes were the frequency and duration of Ch
 rysops landings on clothing and skin. The results of the first trial are a
 s follows: regarding the tested skin-repellents\, blood meal attempts were
  significantly reduced by citriodiol (-50%\, p=0.04) and DEET (-50%\, p<0.
 001)\, but not icaridin (0%\, p=0.48) and IR3535 (0%\, p=0.69). Concordant
 ly\, the time spent by the fly on the skin was significantly shortened by 
 citriodiol (-66%\, p=0.02) and DEET (-46%\, p<0.001)\, but not with icarid
 in (+2%\, p=0.35) and IR3535 (0%\, p=0.93). Conversely\, the number of Chr
 ysops landings on untreated clothing was not reduced by DEET and icaridin\
 , while citriodiol and IR3535 treated individuals experienced a higher num
 ber of landings (p=0.005 and p=0.01\, respectively).\nBecause our study sh
 owed a substantial but not complete protective efficacy of citriodiol and 
 DEET against the bites of loiasis vectors\, whereas icaridin and IR3535 pr
 oofed to be ineffective\, a second trial has recently started to compare t
 he efficacy of the commercial textile-repellents permethrin and icaridin a
 lone or in combination with skin-applied citriodiol and DEET. The availabl
 e results thereof will be also presented here.
BEGIN:VALARM
UID:65623336-6162-4538-b734-613638376162
ACTION:DISPLAY
DESCRIPTION:Loiasis is a parasitic disease caused by the African eye worm L
 oa loa. The disease is endemic to the equatorial rain forest and adjacent 
 areas of Central and West Africa\, where it is transmitted by deer flies o
 f the genus Chrysops. Although more than 23 million people are infected an
 d nearly 42 million live in zones of moderate to high transmission\, there
  are currently no established control tools available to reduce the risk o
 f transmission in endemic regions. Despite the fact that the use of repell
 ents has been explored against other arthropods\, data on their protective
  efficacy against Chrysops bites in humans is lacking. Our group have esta
 blished randomized controlled clinical trial protocols to assess the effic
 acy of four commercial skin-applied and two textile-applied repellents aga
 inst Chrysops bites in a hyperendemic region in Gabon\, Central Africa. In
  the first trial\, volunteers were randomly assigned to apply the skin rep
 ellents DEET\, icaridin\, citriodiol\, IR3535 or an inactive control. The 
 primary endpoint was the number of blood meal attempts by Chrysops flies. 
 Secondary outcomes were the frequency and duration of Chrysops landings on
  clothing and skin. The results of the first trial are as follows: regardi
 ng the tested skin-repellents\, blood meal attempts were significantly red
 uced by citriodiol (-50%\, p=0.04) and DEET (-50%\, p<0.001)\, but not ica
 ridin (0%\, p=0.48) and IR3535 (0%\, p=0.69). Concordantly\, the time spen
 t by the fly on the skin was significantly shortened by citriodiol (-66%\,
  p=0.02) and DEET (-46%\, p<0.001)\, but not with icaridin (+2%\, p=0.35) 
 and IR3535 (0%\, p=0.93). Conversely\, the number of Chrysops landings on 
 untreated clothing was not reduced by DEET and icaridin\, while citriodiol
  and IR3535 treated individuals experienced a higher number of landings (p
 =0.005 and p=0.01\, respectively). Because our study showed a substantial 
 but not complete protective efficacy of citriodiol and DEET against the bi
 tes of loiasis vectors\, whereas icaridin and IR3535 proofed to be ineffec
 tive\, a second trial has recently started to compare the efficacy of the 
 commercial textile-repellents permethrin and icaridin alone or in combinat
 ion with skin-applied citriodiol and DEET. The available results thereof w
 ill be also presented here.
TRIGGER:-PT15M
END:VALARM
END:VEVENT
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