The National Response Framework (NRF) was created to guide the federal government’s response to disasters and emergencies. It is divided into several emergency support functions (ESF) that outline the resources and capabilities necessary for response. The United States Public Health Service (USPHS) Commissioned Corps officers deploy to support public health emergencies both domestically and globally, such as natural disasters, disease outbreaks, and humanitarian assistance missions. Although the USPHS is one of the eight uniformed services of the United States and aligns with ESF #8 – “Public Health and Medical Services”, omission of the service during disaster planning and exercise is evident. The purpose of this project was to explore the level of knowledge of the USPHS capabilities, values, and skillsets to foster interoperability with other organizations allocated to support domestic responses, ultimately facilitating integration into disaster planning and exercises. The project identified partners and areas within domestic response where USPHS officers could collaborate effectively. The theory of change was employed to guide the project in achieving its goals. Selection criteria for stakeholder engagement were aligned with supporting agencies under the ESF #8 which USPHS leadership identified as strategic partners. USPHS officers attended planning meetings alongside their National Guard counterparts providing a platform to share information about the USPHS. Standardized, preapproved information regarding the USPHS history, mission, values, capabilities, structure, and the federal agencies officers serve in was shared with each potential partner. Data gathered during these engagements were organized and analyzed in a formalized document. A repository was created for all documents pertaining to potential collaborations, in preparation for presentation to USPHS leadership for review and approval. Monthly meetings were held at multiple levels and with several internal staff members to discuss current initiatives and the way forward for execution. The project results highlighted the lack of knowledge and appreciation for the value of the USPHS within the agencies under ESF #8, the alignment of shared partnership goals, and the desire of these agencies to partner with the USPHS. These findings were used to execute several joint training/exercise opportunities that support efforts of resource coordination and preparedness of support agencies within the ESF #8. In addition, this project showcased the innovative potential of blending public health expertise with military and civilian resources to solve complex healthcare challenges in remote areas. This work not only strengthens existing collaborations but also opens the door to expanding partnerships with other federal, state, and local entities not considered in the initial criteria. The success of these joint training/exercises has paved the way for the continued inclusion of the USPHS in diverse mission sets, extending beyond traditional healthcare delivery to address comprehensive community health needs and bolster national preparedness efforts. These innovations set a precedent for future engagements where public health and emergency readiness become key drivers of multisector partnerships.